Resultados preliminares de un programa de cribado del cáncer anal y sus precursores en hombres VIH que tienen sexo con hombres en Vigo-España / Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain

Antecedentes y objetivos: los hombres VIH que tienen sexo con hombres (VIH-HSH) presentan la mayor incidencia de cáncer anal (CA). El estudio tiene como objetivo conocer la prevalencia de la infección anal por virus del papiloma humano de alto riesgo (VPH-AR) y de los hallazgos citológicos e histológicos, así como la implementación de un programa de cribado en el contexto de una ciudad media española, Vigo (España). Método: análisis prospectivo de una cohorte de 264 hombres (VIH-HSH). A los pacientes se les realizó una citología anal y genotipado de VPH-AR para el estudio de la prevalencia de alteraciones citológicas y de la infección VPH-AR. A 209 se les realizó una anoscopia de alta resolución (AAR). Los resultados se relacionaron con variables epidemiológicas, clínicas y analíticas. Resultados: de los 209 pacientes seleccionados, la prevalencia de VPH-AR, alteraciones citológicas e histológicas anales fue de 85,6%, 47,5% y 39,3% respectivamente. La sensibilidad y especificidad para la citología ≥ ASCUS (atipia de células escamosas de significado indeterminado) respecto a las alteraciones histológicas fue de 61% y 85% (OR: 8,7; IC95%: 4,4-17,2), respectivamente. La concordancia observada entre la citología HSIL (lesión escamosa intraepitelial de alto grado) e histología HSIL (AIN-2/3, neoplasia intraepitelial tipo 2 y 3) fue del 64%,(OR: 11,4; IC95%: 3,5-36,7). Un paciente con citología HSIL presentó cáncer escamoso anal prevalente. Conclusiones: la AAR resultó factible y con resultados similares a los de grupos relevantes. Gran prevalencia de la infección anal por VPH-AR y de alteraciones citológicas e histológicas (AU)

Background: Men who have sex with men (MSM) infected with human immunodeficiency virus (HIV) have the highest risk of developing anal cancer (AC). The objective of this study was to describe our screening implementation program in this population, and report the prevalence of human papillomavirus (HPV) anal infection, and cytological and histological findings in a Spanish medium-size community (Vigo, Spain). Method: Prospective cohort analysis of 240 HIV-infected MSM. Cellular anal sample and high risk HPV (HR-HPV)-tests were performed to study cytological changes and HPV genotyping. High resolution anoscopy (HRA) was performed in 209 patients. Results were analyzed with respect to epidemiological, clinical and analytical factors. Results: Of 209 patients selected for HRA, the prevalence of HR-HPV anal infection, cytological and histological alterations was 85.6%, 47.5%, and 39.8%, respectively. Sensitivity and specificity for ≥ ASCUS (atypia of squamous cells of undetermined significance) cytology in relation to histological alterations were 61% and 85%, (OR: 8.7; IC 95%: 4.4-17.2), respectively. Observed concordance between high-grade squamous intraepithelial lesion (HSIL) cytology and HSIL anal intraepithelial neoplasia types 2 and 3 (AIN-2/3) histology was 64% (OR: 11.4; IC 95%: 3.6-36.7). One patient with HSIL cytology presented a prevalent anal squamous carcinoma. Conclusions: HRA was feasible with similar results to relevant groups. There was a high prevalence of anal HR-HPV infection, and cytological and histological alterations (AU)

Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain.

BACKGROUND: Men who have sex with men (MSM) infected with human immunodeficiency virus (HIV) have the highest risk of developing anal cancer (AC). The objective of this study was to describe our screening implementation program in this population, and report the prevalence of human papillomavirus (HPV) anal infection, and cytological and histological findings in a Spanish medium-size community (Vigo, Spain). METHOD: Prospective cohort analysis of 240 HIV-infected MSM. Cellular anal sample and high risk HPV (HR-HPV)-tests were performed to study cytological changes and HPV genotyping. High resolution anoscopy (HRA) was performed in 209 patients. Results were analyzed with respect to epidemiological, clinical and analytical factors. RESULTS: Of 209 patients selected for HRA, the prevalence of HR-HPV anal infection, cytological and histological alterations was 85.6%, 47.5%, and 39.8%, respectively. Sensitivity and specificity for ≥ ASCUS (atypia of squamous cells of undetermined significance) cytology in relation to histological alterations were 61% and 85%, (OR: 8.7; IC 95%: 4.4-17.2), respectively. Observed concordance between high-grade squamous intraepithelial lesion (HSIL) cytology and HSIL anal intraepithelial neoplasia types 2 and 3 (AIN-2/3) histology was 64% (OR: 11.4; IC 95%: 3.6-36.7). One patient with HSIL cytology presented a prevalent anal squamous carcinoma. CONCLUSIONS: HRA was feasible with similar results to relevant groups. There was a high prevalence of anal HR-HPV infection, and cytological and histological alterations.

Resultados perinatales asociados a las gestantes infectadas por el virus de la inmunodeficiencia humana en el Complejo Hospitalario Universitario de Vigo / Perinatal outcomes in HIV-positive pregnant women in the Complejo Hospitalario Universitario de Vigo

Introducción: la infección por el virus de la imnunodeficiencia humana (VIH) tiene gran repercusión sobre la reproducción desde el momento de la concepción, por el riesgo de la transmisión sexual, hasta la posible infección del recién nacido. Por ello, es primordial combatir la transmisión vertical durante el embarazo en toda mujer gestante infectada por este virus. Objetivo: conocer la tasa de transmisión vertical, así como estudiar los resultados perinatales asociados a las gestantes infectadas por el VIH en el Complejo Hospitalario Universitario de Vigo. Material y métodos: se realizó un estudio descriptivo retrospectivo de la población gestante afectada por el VIH desde enero de 2000 hasta enero de 2014. Definimos para el estudio variables maternas, gestacionales, intraparto y neonatales. El tratamiento estadístico de los datos fue realizado con el programa SPSS20 para Windows. Resultados: la población estudiada fue de 100 gestantes seropositivas. El 50% presentó coinfección por el virus de la hepatitis C (VHC) y el 9% por el virus de la hepatitis B (VHB). El 98% de las pacientes recibió tratamiento antirretroviral durante el embarazo, el 97% profilaxis intraparto con zidovudina y el 98% de recién nacidos tratamiento antirretroviral desde el nacimiento. El 45% de los casos cumplió criterios para un parto vaginal. Finalmente, el 28% fueron partos eutócicos y el 4%, instrumentados; en el 13% restante se indicó cesárea urgente intraparto. La transmisión materno-fetal fue del 0%. Conclusión: protocolizar el manejo gestacional y neonatal en las pacientes seropositivas frente al VIH ha permitido obtener un importante descenso en su tasa de transmisión vertical (AU)

Introduction: Human Immunodeficiency Virus (HIV) infection has a major impact on reproduction that includes the risk of sexual transmission at conception and even possible infection of the newborn. Consequently, it is essential to combat vertical transmission during pregnancy in all HIV-infected pregnant women. Objective: The objective of this study was to determine the rate of vertical transmission and perinatal outcomes in HIV-infected pregnant women attended at the University Hospital of Vigo. Material and methods: A retrospective descriptive study was conducted in HIV- pregnant women from January 2000 to January 2014. Maternal, gestational, intrapartum and neonatal variables were defined for the study. The statistical analysis of the data was carried out with SPSS version 20 for Windows. Results: The study population consisted of 100 HIV-seropositive pregnant women. Fifty percent were coinfected with the hepatitis C virus (HCV) and 9% with the hepatitis B virus (HBV). Most (98%) of patients received antiretroviral therapy during pregnancy, 97% received intrapartum prophylaxis with zidovudine and 98% of newborns received antiretroviral treatment from birth. Forty-five percent of the patients met the criteria for vaginal delivery. Delivery was normal in 28% and instrumental in 4%, while intrapartum emergency caesarian section was required in the remaining 13%. Maternal-fetal transmission was 0%. Conclusion: Protocolizing gestational and neonatal management in HIV-seropositive patients significantly decreased the rate of vertical transmission (AU)

Consideraciones prácticas de la anoscopia de alta resolución en pacientes infectados por el virus de la inmunodeficiencia humana / Practical considerations for high resolution anoscopy in patients infected with human immunodeficiency virus

El cáncer de ano, una enfermedad infrecuente en la población general, presenta una incidencia elevada y progresiva en ciertos grupos de riesgo, fundamentalmente en hombres que tienen sexo con hombres, y particularmente en aquellos con infección por el virus de la inmunodeficiencia humana. La anoscopia de alta resolución se considera actualmente la técnica estándar en el diagnóstico de la neoplasia intraepitelial anal, pero su uso protocolizado aún está por consensuar en los sistemas sanitarios. Aunque no está exenta de dificultades, es una técnica asequible que puede llegar a ser fundamental en el cribado del cáncer de ano y sus lesiones precursoras. Actualmente estamos estudiando la estrategia más efectiva para el manejo de las lesiones premalignas anales, y con esta publicación intentamos animar a otros grupos interesados en la reducción de una neoplasia epidemiológicamente en progresión

Anal cancer is uncommon in the general population, however its incidence is increasing significantly in certain risk groups, mainly in men who have sex with men, and particularly those infected with human immunodeficiency virus. High resolution anoscopy technique is currently considered the standard in the diagnosis of anal intraepithelial neoplasia, but at present there is no agreed standard method between health areas. High resolution anoscopy is an affordable technique that can be critical in the screening of anal carcinoma and its precursor lesions, but is not without difficulties. We are currently studying the most effective strategy for managing premalignant anal lesions, and with this article we attempt to encourage other groups interested in reducing the incidence of an increasing neoplasia

[Practical considerations for high resolution anoscopy in patients infected with human immunodeficiency virus]. / Consideraciones prácticas de la anoscopia de alta resolución en pacientes infectados por el virus de la inmunodeficiencia humana.

Anal cancer is uncommon in the general population, however its incidence is increasing significantly in certain risk groups, mainly in men who have sex with men, and particularly those infected with human immunodeficiency virus. High resolution anoscopy technique is currently considered the standard in the diagnosis of anal intraepithelial neoplasia, but at present there is no agreed standard method between health areas. High resolution anoscopy is an affordable technique that can be critical in the screening of anal carcinoma and its precursor lesions, but is not without difficulties. We are currently studying the most effective strategy for managing premalignant anal lesions, and with this article we attempt to encourage other groups interested in reducing the incidence of an increasing neoplasia.

Pancreatitis de repetición en paciente con infección por el virus de la inmunodeficiencia humana en tratamiento antirretroviral / Recurrent pancreatitis in a human immunodeficiency virus-infected patient on antiretroviral therapy

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[Hypersensitivity reactions to antiretroviral agents in HIV-infected patients]. / Reacciones de hipersensibilidad a antirretrovirales en pacientes con infección por el virus de la inmunodeficiencia humana.

Drug hypersensitivity reactions in the HIV-positive patient are a major problem in management of these patients and, nowadays the antiretroviral agents are the main cause of those reactions, exceeding cotrimoxazole. The present review focuses on immunologic reactions that have been reported associated with antiretroviral agents. We have reviewed case reports on Medline(R) to September 2005. Evidence that these reactions are immune mediated is largely based on the typical symptomatology and few studies have been done to determine the pathogenesis mechanisms. The clinical management of this type of reactions is complex because of differential diagnosis and of potential severity. It is essential that research is now carried out into the pathogenic mechanisms and so, we shall be able to offer an efficacious protocol to manage these situations.

Reacciones de hipersensibilidad a antirretrovirales en pacientes con infección por el virus de la inmunodeficiencia humana / Hypersensitivity reactions to antiretroviral agents in HIV-infected patients

Las reacciones de hipersensibilidad a fármacos en pacientes infectados por el virus de la inmunodeficiencia humana constituyen un importante problema en el manejo de este colectivo. En la actualidad las relacionadas con los antirretrovirales superan a las del cotrimoxazol. El objetivo de esta revisión fue recopilar lo publicado sobre reacciones adversas a antirretrovirales de presumible origen inmunológico. Para ello, se realizó una búsqueda bibliográfica en la base de datos Medline® hasta septiembre de 2005. La naturaleza inmunitaria de estas reacciones se presupone por las características clínicas y existen pocos estudios que analicen su fisiopatología y definan los mecanismos inmunológicos implicados. El manejo clínico de estas reacciones es complejo, fundamentalmente en relación con su diagnóstico diferencial y su potencial gravedad. Es necesario concentrar los esfuerzos investigadores para dilucidar los mecanismos patogénicos subyacentes y así poder ofertar estrategias de manejo a los clínicos que se enfrentan a estas situaciones

Drug hypersensitivity reactions in the HIV-positive patient are a major problem in management of these patients and, nowadays the antiretroviral agents are the main cause of those reactions, overcoming to cotrimoxazole. The present review focuses on immunologic reactions that have been reported associated with antiretroviral agents. We have reviewed case reports on Medline® to September 2005. Evidence that these reactions are immune mediated is largely based on the typical symptomatology and few studies have been done to determine the pathogenesis mechanisms. The clinical management of this type of reactions is complex because of differential diagnosis and of potential severity. It is essential that research is now carried out into the pathogenic mechanisms and so, we shall be able to offer an efficacious protocol to manage these situations

Valor predictivo de la candidiasis oral como marcador de evolución a SIDA / Predictive value of oral candidiasis as a marker of progression to AIDS

Objetivo: Determinar la validez de la candidiasis oral (CO) como marcador clínico de evolución en los pacientes infectados porel Virus de la Inmunodeficiencia Humana. Diseño del estudio: En 1992, se efectuó una exploración oral a un colectivo de 200 pacientes infectados por VIH, con una edad media de 36,8±7 años (rango 25-46 años) para establecer el diagnóstico de CO. Se registraron las variables edad, sexo, tiempode evolución de la enfermedad, conducta de riesgo, número de linfocitos CD4/µL, estadio clínico y tratamiento antirretroviral. De los 200 pacientes del grupo de estudio, 157 no cumplían criterios de SIDA en el momento de la exploración basal y a éstos se les efectuó un seguimiento semestral hasta que cumplieron dichos criterios, concluyendo el estudio al final de 2001. Resultados: De los 157 pacientes seleccionados, 71 (45,2%) no presentaron CO y de éstos el 28,7% evolucionó a SIDA durante el período de seguimiento. De los 86 (54,8%) pacientes con CO, el 48,2% evolucionó a SIDA (RR=2,71). Al trasladar el origen del estudio al año 1997 cuando se inició la administración de la terapia antirretroviral de alta eficacia (TAAE), no se observaron diferencias en el porcentaje de pacientes que evolucionaron a SIDA en relación a la existencia o no de CO en la exploración basal. El análisis multivariante demostró que la asociación de la variable de exposición CO con la evolución a SIDA no alcanzó un valor predictivo. Conclusiones: El valor pronóstico a largo plazo de la CO, no se ha determinado en pacientes que reciben terapia antirretroviral de alta eficacia (TAAE). La recuperación inmunológica y la disminución de enfermedades oportunistas observadas tras la administración de TAAE, hacen que muchos pacientes que alcanzaron la condición de SIDA no cumplan en la actualidad dichos criterios, lo que obliga a renovar la propia definición del síndrome para poder evaluar marcadores de pronóstico

Objective: To determine the validity of oral candidiasis (OC) as a clinical marker of progression in patients with human immunodeficiency virus infection. Study design: In 1992, an oral examination was carried out on a group of 200 HIV-infected patients with a mean age of 36.8± 7 years (range 25-46 years) to establish the diagnosis of OC. The following variables were recorded: age, sex, duration of the disease, risk behaviour, CD4 lymphocyte count, clinical stage and antiretroviral treatment. Of the 200 patients in the groupe valuated, 157 did not fulfil the criteria for AIDS at the time of the base line examination; these patients constitute the study group and underwent 6-monthly follow-up until they fulfilled these criteria. The study was concluded at the end of 2001. Results: Of the 157 patients selected, 71 (45.2%) did not present OC and, of these, 28.7% progressed to AIDS during the follow up period. Of the 86 (54.8%) patients with OC, 48.2% progressed to AIDS (RR= 2.71). If the start date of the study was taken as 1997, when highly active antiretroviral therapy (HAART) was introduced, no differences were found in the percentage of papatients who progressed to AIDS with respect to the presence or absence of OC at the baseline examination. Multivariate analysis demonstrated that the association of the presence of OC with progression to AIDS did not reach a predictive value. Conclusions: The long-term prognostic value of OC has notbeen established in patients receiving highly active antiretroviral therapy (HAART). The immunological recovery and the reduction in the number of opportunistic diseases observed after the administration of HAART means that many patients who developed AIDS do not currently satisfy these criteria, making a review of the definition of the syndrome it self a necessity in order to be able to evaluate prognostic markers

Predictive value of oral candidiasis as a marker of progression to AIDS.

OBJECTIVE: To determine the validity of oral candidiasis (OC) as a clinical marker of progression in patients with human immunodeficiency virus infection. STUDY DESIGN: In 1992, an oral examination was carried out on a group of 200 HIV-infected patients with a mean age of 36.8 +/- 7 years (range 25-46 years) to establish the diagnosis of OC. The following variables were recorded: age, sex, duration of the disease, risk behaviour, CD4 lymphocyte count, clinical stage and antiretroviral treatment. Of the 200 patients in the group evaluated, 157 did not fulfil the criteria for AIDS at the time of the baseline examination; these patients constitute the study group and underwent 6-monthly follow-up until they fulfilled these criteria. The study was concluded at the end of 2001. RESULTS: Of the 157 patients selected, 71 (45.2%) did not present OC and, of these, 28.7% progressed to AIDS during the followup period. Of the 86 (54.8%) patients with OC, 48.2% progressed to AIDS (RR= 2.71). If the start date of the study was taken as 1997, when highly active antiretroviral therapy (HAART) was introduced, no differences were found in the percentage of patients who progressed to AIDS with respect to the presence or absence of OC at the baseline examination. Multivariate analysis demonstrated that the association of the presence of OC with progression to AIDS did not reach a predictive value. CONCLUSIONS: The long-term prognostic value of OC has not been established in patients receiving highly active antiretroviral therapy (HAART). The immunological recovery and the reduction in the number of opportunistic diseases observed after the administration of HAART means that many patients who developed AIDS do not currently satisfy these criteria, making a review of the definition of the syndrome itself a necessity in order to be able to evaluate prognostic markers.

[Retrospective epidemiological study on the durability of the treatment of HIV infection or AIDS in Spain]. / Estudio epidemiológico retrospectivo sobre la duración del tratamiento de la infección por el virus de la inmunodeficiencia humana en España.

BACKGROUND AND OBJECTIVE: To know the durability of consecutive regimens of antiretroviral treatment is important to design a long-term therapy, but there is not much information about this subject. PATIENTS AND METHOD: Retrospective epidemiological study of a sample of 401 patients who began antiretroviral treatment between January 1997 and April 2000 at ten Spanish hospitals. The duration of each consecutive antiretroviral regimen was calculated and the reasons for modification and discontinuation were described. RESULTS: In the 3 years and 3 months covered by the study, 48.6% of the patients received more than one regimen of therapy. Seventy five of the initial prescribed combinations included protease inhibitors. Median duration of consecutive lines of therapy was decreasing: 560, 360, 330 and 202 days for the first, second, third and fourth regimens, respectively. The main reason to modification was intolerance or toxicity (46.2, 49.1 and 47.1% for the first, second and third modification). A fifth of changes was originated by difficulties to follow the therapy. Virological failure was the reason for modification in 21.8, 24.5 and 26.5% of first, second and third changes. CONCLUSIONS: Duration of consecutive antiretroviral regimens progressively decreases. Intolerance or drug toxicity were the main reasons conditioning the change of treatment.

Alteraciones cuantitativas y funcionales de los neutrófilos

El neutrófilo es una célula implicada en el mantenimiento de la homeostasis del organismo, con un especial protagonismo en el control y eliminación de determinados microorganismos patógenos. Los déficits cuantitativos y funcionales de los neutrófilos pueden ser congénitos o secundarios a factoresetiológicos extrínsecos, y se traducen en procesos infecciosos recurrentes de severidad variable. Las complicaciones orales más frecuentes en estos pacientes son las aftas, la enfermedad periodontal y la candidiasis. Por su elevada susceptibilidad a las infecciones y el riesgo que conllevan las manipulaciones quirúrgicas, en este colectivo deben intensificarse las acciones de carácter profiláctico (hábitos de higiene oral, fluorizaciones, recomendaciones dietéticas, etc.). El empleo de factores estimuladores de colonias de granulocitos (G-CSF) permite en algunos casos la realización de procedimientos odontológicos hasta hace poco muy controvertidos; su administración exige una adecuada selección de pacientes y una estrecha colaboración entre el médico y el odontólogo. A pesar de la eficacia del G-CSF, el tratamiento odontológico de los pacientes con alteraciones severas de los neutrófilos cuantitativas y/o funcionales debe efectuarse en medio hospitalario. En ocasiones, la progresión de la enfermedad periodontal es inevitable a pesar de un adecuado mantenimiento (AU)